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377: Why Everything You Think About Aging May Be Wrong with Dr. Charles Brenner

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377: Why Everything You Think About Aging May Be Wrong with Dr. Charles Brenner

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The second half of your life can bring some of your most rewarding decades. But when it comes to healthy aging and your diet, there are plenty of mixed up “facts” that need to be unraveled. In this episode, our special guest Dr. Charles Brenner separates nutrition fact from fiction and explain the science of aging better. Listen now!


Brief Bio:

Our guest today is Dr. Charles Brenner, the Roy J. Carver Chair of Biochemistry at the University of Iowa.

Charles is one of the world’s leading experts on nicotinamide adenine dinucleotide, commonly referred to as NAD, which is an essential molecule found in every living cell.  In 2004, he discovered the nicotinamide riboside kinase pathway, which leads to a special form of vitamin B3.

We talk to Charles about his research into NAD and why he believes supplementation with NR could help people age better. In addition to his work at the University of Iowa, he is also the chief scientific advisor for ChromaDex, which markets the NR supplement Tru Niagen.



In this episode, you’ll learn:

  • Triage Theory [14:08-15:00]
  • Healthy aging, resilience, and well being. [15:22-23:55]
  • Why there is an obesity epidemic [18:07-21:31]
  • What is NAD and why should you care [23:56-30:33]
  • Metabolic stress [29:49-30:12]
  • Replenishing NAD with three precursor supplements [30:09-30:33]
  • Who should be taking NAD supplements [31:01-41:35]
  • What is Palabras & its four Ds [37:12-38:24]
  • The differences between Nicotinamide, Niacin, and Nicotinamide Riboside [41:35-49:36]
  • The dosage and effects of NAD supplements [51:52-58:48]
  • NR as proven to improve health and wellness [58:49-01:06:55]
  • Are there contraindications of Niagen supplement? [01:07:00-01:09:31]
  • Resveratrol Supplements versus NR Supplements [01:09:42-01:11:58]
  • Should diabetics should not be taking Metformin [01:12:22-]
  • Tips to evaluate the right information and avoid the false one [01:16:57-01:20:52]
  • How to be more science-based evidence [01:22:21-01:26:50]
  • And much more…



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Links Mentioned:

Legendary Life Program

Tru Niagen

About NAD


Connect with Charles:






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Ted Ryce is a high-performance coach, celebrity trainer, and a longevity evangelist. A leading fitness professional for over 24 years in the Miami Beach area, who has worked with celebrities like Sir Richard Branson, Rick Martin, Robert Downey, Jr., and hundreads of CEOs of multimillion-dollar companies. In addition to his fitness career, Ryce is the host of the top-rated podcast called Legendary Life, which helps men and women reclaim their health, and create the body and life they deserve.

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